In futuristic Pittsburgh, Warlash, a biomechanical hybrid warrior, attempts to track down what seems to be a serial killer committing mysterious human mutilations. He soon discovers a rogue geneticist is breeding an army of deadly Zombie Mutants. These genetic monstrosities are not only feeding on the weak, but also changing select humans into an horde of deadly mutating beasts. As the city descends into chaos, Warlash must battle his way to the underground breeding facility and destroy it before it's too late.